Antibiofilm activity of essential oils in Candida spp. : a literature review

Species of the genus Candida, despite part of the normal human microbiota, can cause important fungal infections ranging from superficial clinical manifestations to fatal invasive lesions. Most of these infections are related to the ability of Candida spp. To form biofilm, which results in increased resistance to antifungal agents, such as ketoconazole, amphotericin b and fluconazole, hindering proper treatment. The increase in these infections together with increased resistance to antifungal drugs has made it necessary to seek new therapeutic alternatives. Among the new alternatives is the search for essential oils of plants that have antibiofilm properties. A search was performed in the Science direct, Scopus, PubMed and Scielo databases. From this search, a total of 39 essential oils were found, related to antibiofilm activity in front of Candida species, among them are lemon grass, eucalyptus, cinnamon and tea tree oils. The data found in this review demonstrated the antibiofilm activity of most essential oils, suggesting that they can be used as new treatment alternatives and reinforcing the need for further studies to prove their efficacy

Central odontogenic fibroma : an international multicentric study of 62 cases

OBJECTIVE : The aim of this study was to report the clinicopathologic features of 62 cases of central odontogenic fibroma (COdF). STUDY DESIGN : Clinical and radiographic data were collected from the records of 13 oral pathology laboratories. All cases were microscopically reviewed, considering the current World Health Organization classification of tumors and were classified according to histopathologic features. RESULTS : There were 43 females and 19 males (average age 33.9 years; range 8–63 years). Clinically, COdF lesions appeared as asymptomatic swellings, occurring similarly in the maxilla (n = 33) and the mandible (n = 29); 9 cases exhibited palatal depression. Imaging revealed well-defined, interradicular unilocular (n = 27), and multilocular (n = 12) radiolucencies, with displacement of contiguous teeth (55%) and root resorption (46.4%). Microscopically, classic features of epithelial-rich (n = 33), amyloid (n = 10), associated giant cell lesion (n = 7), ossifying (n = 6), epithelial-poor (n = 3), and granular cell (n = 3) variants were seen. Langerhans cells were highlighted by CD1a staining in 17 cases. Most patients underwent conservative surgical treatments, with 1 patient experiencing recurrence. CONCLUSIONS : To the best of our knowledge, this study represents the largest clinicopathologic study of COdF. Most cases appeared as locally aggressive lesions located in tooth-bearing areas in middle-aged women. Inactive-appearing odontogenic epithelium is usually observed within a fibrous/fibromyxoid stroma, occasionally exhibiting amyloid deposits, multinucleated giant cells, or granular cells.http://www.journals.elsevier.com/oral-surgery-oral-medicine-oral-pathology-and-oral-radiology2021-08-27hj2021Oral Pathology and Oral Biolog